Total chemical synthesis of proteins

Brik, Ashraf (editor.). Dawson, Philip (editor.). Liu, Lei, 1977- (editor.).

Summary: With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins.

Record details

ISBN: 9783527346608 (hardcover)
Physical Description: print
xv, 604 pages : illustrations (some color) ; 25 cm
Publisher: Weinheim, Germany : Wiley-VCH, [2021]
Copyright: ©2021

Content descriptions

Bibliography, etc. Note:

Includes bibliographical references and index.

Formatted Contents Note:

Characterization of protein molecules prepared by total chemical synthesis -- Automated fast flow peptide synthesis -- N, S- and N, Se-Acyl transfer devices in protein synthesis -- Chemical synthesis of proteins through native chemical ligation of peptide hydrazides -- Chemical synthesis of proteins through native chemical ligation of peptide hydrazides -- Expanding native chemical ligation methodology with synthetic amino acid derivatives -- Peptide ligations at sterically demanding sites -- Controlling segment solubility in large protein synthesis -- Toward HPLC-free total chemical synthesis of proteins -- Solid-phase chemical ligation -- Ser/Thr ligation for protein chemical synthesis -- Protein semisynthesis -- Bio-orthoganl imine chemistry in chemical protein synthesis -- Deciphering protein folding using chemical protein synthesis -- Chemical synthesis of ubiquitinated proteins for biochemical studies -- Glycoprotein synthesis -- Chemical synthesis of membrane proteins -- Chemical synthesis of selenoproteins -- Histone synthesis -- Application of chemical synthesis to engineer protein backbone connectivity -- Beyond phosphate esters : synthesis of unusually phosphorylated peptides and proteins for proteomic research -- Cyclic peptides via ligation methods.